Frontiers | Synaptic remodeling generates synchronous ...

2014-9-5 · During neuronal degenerative diseases, neuronal microcircuits undergo severe structural alterations, leading to remodeling of synaptic connectivity. The functional consequences of such remodeling are mostly unknown. For instance, …

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(PDF) Glutamate and Glutamate Receptors in the …

receptors is similar to that described for glutamate transporters, because. the glutamate-elicited current is: 1) dependent upon external Na +; 2) reduced by transporter blockers; and 3 ...

Mechanism for Selective Synaptic Wiring of Rod ...

2015-9-23 · In contrast, we found no evidence for ON-RBC contacting cone pedicles in either WT or Elfn1 KO retinas (45 and 65 ON-RBC neurons examined, in WT and Elfn1 KO retinas, respectively). We conclude that recruitment of mGluR6 by ELFN1 is required specifically for ON-RBCs to establish synaptic contacts with rod axonal terminals.

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Development and diversification of bipolar interneurons in ...

Although cone-to-cone bipolar connections form without visual cone responses, sensory deprivation does impact photoreceptor-to-bipolar circuit maturation. Dark-reared animals have reduced synaptic strength between cones and cone bipolar subtypes, but rod to RBC connections are unaffected (Dunn and Wong, 2012). Different subtypes of cone ...

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Relief of Mg2+-Dependent Inhibition of TRPM1 by PKCα …

2011-9-21 · In the retina, light onset hyperpolarizes photoreceptors and depolarizes ON bipolar cells at the sign inverting photoreceptor–ON bipolar cell synapse. Transmission at this synapse is mediated by a signaling cascade comprised of mGluR6, a G-protein containing Gαo, and the cation channel TRP melastatin 1 (TRPM1). This system is thought to be common to both the …

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(PDF) Synaptic Remodeling Generates Synchronous ...

2014-9-5 · the activity of RBCs and the number of cone-RBC clusters (see. Ta b l e s 2, 3;c f.a l s o Figures 6E,F), likely due to a reduction of inhi-bition …

Mechanism for selective synaptic wiring of rod ...

In contrast, we found no evidence for ON-RBC contacting cone pedicles in either WT or Elfn1 KO retinas (45 and 65 ON-RBC neurons examined, in WT and Elfn1 KO retinas, respectively). We conclude that recruitment of mGluR6 by ELFN1 is required specifically for ON-RBCs to establish synaptic contacts with rod axonal terminals.

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